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Fingolimod induces neuroprotective factors in human astrocytes

UK guidance (MHRA and NICE) advises checking B12 levels in patients on metformin who develop symptoms of deficiency (anaemia, neuropathy) and considering periodic monitoring in those on long-term therapy

Two biological replicates were performed

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch

This 12 week study with a 40 week extension period revealed that the addition of vildagliptin significantly lowered HbA1c levels by week 12, with the improvement being sustained to the end of the study period, whereas glycaemic control deteriorated in the placebo recipients (34)

Kyoto, JP