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Patients Lost 31LBS on Average In a trial with 1,387 patients who were obese but did not have Type 2 diabetes, patients were randomly assigned to different doses of Semaglutide

A 2022 review reported that no adverse side effects in humans have been detected yet

Furthermore, Yoon et al

2,20 Antifibrotic Effects GLP-1RAs downregulate transforming growth factor- signalling pathways in myocardial fibrosis

In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

Guideline for perioperative care for people with diabetes mellitus undergoing elective and emergency surgery