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With rapid weight loss (without taking a GLP-1) comes muscle wasting

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The interaction effects between the nutritional state and L-carnitine were observed in the mRNA levels of IL-1 and TGF-1 in liver and TNF- in muscle (Supplemental Table 6)

The SURMOUNT trials in patients without diabetes showed even greater weight loss, with the 15 mg dose producing an average loss of 20.9 percent of body weight at 72 weeks compared to 14.9 percent for semaglutide in similar populations

Ive heard that it can cause new moles, or darkening of existing moles, which raises concerns about melanoma risk