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Activated charcoal: May help reduce gas, although the evidence is mixed

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Phase 2 orforglipron data demonstrated 14.7% body weight reduction at 45mg without food or water requirements, and the addressable patient expansion is estimated to grow the anti-obesity medication market by 180 million new prescription patients between 2027 and 2032

In the Phase 2 paper there was no clear depression signal, but a letter to the editor in The Lancet noted that the trial excluded patients with psychiatric histories, which makes the safety estimate look better than it might be in a general population

Neither medication should be used in individuals with a personal or family history of these conditions

HSA/FSA coverage for off-label weight-loss use is murkier