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Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

PubMed Leyden J et al

doi:10.1038/s41574-020-0381-5 Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI

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Because the faces subcutaneous fat is not replaced or redistributed, the skin that once rested on a supportive scaffold now hangs loosely, producing the characteristic look

University of Arizona