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In animal models it was shown that down-regulation of the GH/IGF-1/insulin system significantly prolongs the lifespan

Biomed Res Int 2015:835761 Demirbas A, Edris G (2017) Biofuels production from microalgae by liquefaction and supercritical water pyrolysis

& Keshari, K

And for good reason

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Levels of glutathione within the cells and mitochondria are highly associated with health and longevity, and its deficiency is associated with loss of function with aging and many chronic diseases (including depression, anxiety, Alzheimers, Parkinsons, heart disease, and even cancer)