Can you just remind folks how they work
Semaglutide# Semaglutide is a synthetic GLP-1(7-37) analog with an Aib substitution at position 8 for DPP-4 resistance and a C18 fatty diacid chain at lysine-26 for albumin binding, giving it a half-life of approximately 7 days
As of 2024, clinical trials have not shown a signal for increased thyroid cancer risk with Zepbound, but ongoing surveillance continues
Patient safety advice includes: Maintaining good injection technique and site rotation to minimise local reactions Staying up to date with routine vaccinations, including annual influenza and pneumococcal vaccines as recommended for people with diabetes Monitoring for signs of infection and seeking prompt medical advice if concerned Following 'sick day rules' during illness maintain hydration, continue medication if possible, but temporarily pause GLP-1 treatment if unable to keep fluids down Reporting suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app) Patients should not discontinue their GLP-1 receptor agonist due to concerns about immune function without first consulting their prescribing clinician
Conversely, when leptin is administered to animals the level of CART mRNA in the ARC increases
And thats assuming the product is actually liposomal which many arent
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