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Current drug metabolism , 12 (7), 667678.
the appetite-suppressing effects of GLP-1 agonists require careful consideration Medication absorption : Delayed gastric emptying may theoretically affect the absorption of oral Crohn's disease medications, though clinical significance remains unclear Ongoing monitoring strategies include: Symptom diary : Patients should maintain records distinguishing new gastrointestinal symptoms from their baseline Crohn's pattern Faecal calprotectin testing : When clinically indicated to differentiate inflammatory activity from functional symptoms, in line with NICE DG11 guidance Nutritional surveillance : Regular assessment of weight, body composition, and nutritional markers (albumin, vitamins, minerals) Dose titration : Slower than standard dose escalation may improve gastrointestinal tolerability Collaborative care between gastroenterology and diabetes/obesity services is strongly recommended

International Product Manager, MEQU/1947 Senior Safety Manager Pharmacokineticist, PK/PD Modelling & Simulation Laboratoriechef Pharma, Kosmetik & Helse, Biofac/1948 Global Clinical Lead, Clinical Development, Migraine & Pain Clinical Supply Manager Senior P&C Business Partner Senior Medical Specialist, Therapeutic Areas - Global Clinical Development You need to be a subscriber to read the rest of the article.
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While dedicated renal outcome trials for tirzepatide are not yet completed, post-hoc analyses from the SURPASS program suggest potential effects on urinary albumin excretion