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What is Dysesthesia
IGF1 increases hypothalamic and pituitary responses to GnRH, thereby potentially increasing LH and FSH secretion
In a pre- and postnatal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (0.2-, 1-, and 3-fold the MRHD) were administered from Gestation Day 16 to 140
Independent sample t -tests were used for comparison
GI side effects may temporarily increase during the transition because tirzepatide adds GIP receptor activation
The time of day does not matter, but many patients find it easiest to inject around the same time as well
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