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Also, IGFBPrPs have been associated with insulin resistance and fasting glucose levels [179, 180]

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The cytotoxic payload, typically a microtubule inhibitor (auristatin, maytansinoid) or a topoisomerase I inhibitor (camptothecin derivative), is subject to its own composition and method-of-synthesis patent landscape

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Alternative integrin signaling IGF not only binds to IGF-IR/InsR, but also directly binds to other receptors such as integrin, a family of adhesive receptors that promotes cancer stemness and cell survival to adapt to environmental and therapeutic stresses [170, 171]

Oral administration Oral delivery is the most convenient route but presents bioavailability challenges