doi: 10.1007/s10787-024-01499-8
This means oral supplementation with crystalline B12 can be effective even when food-bound B12 absorption is impaired
Higher, clinically studied doses (500mg or more) tend to show results more reliably
It participates in the modulation of the activity and localization of numerous enzymes and receptors [147, 160, 161], takes part in the regulation of many physiological processes in the brain [147, 162], including synaptic plasticity [163, 164], axonal elongation, and neuronal survival [147, 165]
W.ZlokovicB
Subsequent research clarified that while Dihexa interacts with the angiotensin IV system, its cognitive effects are primarily mediated through the HGF/c-Met pathway