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In some cases, gynecomastia resolves naturally, especially in adolescents, but persistent cases may necessitate further intervention

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N Engl J Med 392(6):612615 Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, Thomas MK, Hartman ML, Haupt A, Milicevic Z, Coskun T (2023) Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

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High levels of Ca 2+ are brought to the nucleus by CaM where it will cause DNA fragmentation and lead to necrosis (Nicotera et al