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All experiments with mice were performed according to the protocols approved by the Committee of Animal Experiments of Osaka University (approval number 02-001-003), in accordance with the National Institutes of Health Guide for Care and Use of Laboratory Animals

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To characterize the class-level safety profile, K-Dense Web performed a Proportional Reporting Ratio (PRR) disproportionality analysis using the openFDA FAERS API, comparing semaglutide and tirzepatide across six safety signals from 2020 through April 2026

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Real-World Evidence of GLP-1 RA Therapy in T2D A substantial body of data in real-world settings supports the efficacy and safety of GLP-1 RAs evidenced from the randomised controlled trials (RCTs)

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