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El-Beltagi et al., 2020
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WO 00/53148 (Merck) discloses and claims a "method for the treatment of erectile dysfunction which comprises administering to a human subject in need of such treatment an effective amount of an agonist of the melanocortin receptor in combination with an effective amount of a cyclic-GMP- specific phosphodiesterase inhibitor or an alpha-andrenergic receptor antagonist." MT-II is a disclosed melanocortin receptor agonist and sildenafil is a disclosed PDE-5 inhibitor
Oral semaglutide requires a higher dose than injectable medication since the bioavailability is lower
