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These drugs have significant side effects, many very unpleasant (sometimes unpleasant enough for people to quit the drugs,) some severe, some life-threatening

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In summary, while both medications offer benefits for type 2 diabetes and weight management, tirzepatides dual receptor agonism may provide enhanced glycemic control and weight loss outcomes compared to semaglutide

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Participants were randomized to receive 3 mg, 7 mg, or 14 mg of oral semaglutide or 100 mg of sitagliptin once daily