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Preliminary communication

Nevertheless, their therapeutic potentials are still subject of debate, particularly given their known gastrointestinal side effects (e.g., nausea, vomiting, and diarrhea), which may limit their application in IBD patients, especially those with clinically active disease (14)

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Heightened Fatigue: Some individuals experience GLP-1 fatigue as the medication reaches its peak

Collect baseline and follow-up (e.g., 1, 3, 6, 12 months) vaginal symptom PROMs, vaginal pH, microbiome sequencing, HbA1c, hydration markers, sex hormones (oestradiol/estrone/SHBG), and weight trajectory

We further demonstrated that this GPX4 activator can decrease the intracellular ROS level and suppress ferroptosis