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In a randomized trial, patients with laryngopharyngeal reflux disease (LPRD) were enrolled were given oral vonoprazan and saliva specimens were collected before and after treatment, and Neisseria, Burkholderia , and Leptospira were found to be more prevalent in the LPRD group than in the post-LRPD group

pmid:14657002 9

however, clinical trials in humans are very limited

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Physiology, Gluconeogenesis