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This review highlights NAD+ as a central regulator of energy metabolism, mitochondrial function, and cellular repair, demonstrating that age-related declines in NAD+ may contribute to chronic disease, while supplementation with NAD+ boosters shows potential for reducing age-related decline and disease
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however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing
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