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The production of significant lactate by tumor cells is due to glycolysis, which serves as an intermediary between tumor cells and TAMs, thereby enhancing M2-like polarization through hypoxia-inducible factor 1 (HIF1) [64]

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It neutralizes free radicals that damage the skin causing aging and dark skin pigmentation and it helps in the regeneration of skin cells

Mongongu et al

doi: 10.1016/j.phrs.2019.104615 146 DuarteAICandeiasEAlvesINMenaDSilvaDFMachadoNJet al

Structure-activity relationships of cyclic lactam analogues targeting melanocortin receptor models