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Originally developed for type 2 diabetes, GLP-1 receptor agonists, like semaglutide, work by stimulating insulin release, slowing digestion, and signaling fullness in the brain

Skin-related side effects such as rashes or injection site irritation have also been documented

Outcomes 16 , e009078 (2023)

The idea of using a metric such as the clinically meaningful change can be applied to assess whether the outcome is not only statistically relevant, but would be meaningful to a person with a particular disease