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In rats subjected to experimental hypoxia, a significant stress-mediated reduction in both the rate of phosphorylated respiration (V3, a 20% decrease) and the rate of ADP phosphorylation (ADP/t, a 31% decrease) was observed in brain mitochondria
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Their potencies against LXR and LXR were evaluated in biochemical binding assays, cellular mammalian two-hybrid interaction assays evaluating nuclear receptor co-repressor (NCOR) recruitment and cellular reporter assays evaluating transcriptional activity (Fig
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