In most studies on IGF-1 Lr3 no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.
A meta-analysis of 10 studies, using myoinositol or di-chiro-inositotol in 2017 reported many positive benefits for women with PCOS
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Gromer S, Arscott LD, Williams CH Jr, Schirmer RH, Becker K (1998) Human placenta thioredoxin reductase
J Infect Dis 212:128136 Marion R, Coffier M, Gargala G, Ducrott P, Dchelotte P (2004) Glutamine and CXC chemokines IL-8, Mig, IP-10 and I-TAC in human intestinal epithelial cells