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Semaglutide mimics the GLP-1 hormone that is released in the gastrointestinal tract in response to eating
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GLP-1 receptor agonists are peptide-based molecules metabolised by proteolytic degradation rather than hepatic cytochrome P450 enzymes, meaning they do not directly interfere with the metabolism of calcineurin inhibitors or other immunosuppressive drugs
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However, significant or rapid rises in PSA during testosterone therapy warrant further investigation to rule out other causes
Common side effects include nausea, vomiting, diarrhea, and mild stomach discomfort
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