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In a Phase IIb, dose-finding, randomised, placebo-controlled trial (SYNERGY-NASH) involving 190 participants with obesity and biopsy-confirmed MASH and stage F2 or F3 fibrosis, once-weekly subcutaneous tirzepatide (5 mg, 10 mg or 15 mg for 52 weeks) resulted in significantly higher rates of MASH resolution without worsening of fibrosis (44%, 56% and 62%, respectively) than placebo (10%)

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