If I understand rightly you haven't an absorption problem.So once on supplements or a richer B12 diet you can store and utilise b12 from your liver
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Gastrointestinal Health Surveillance: Close monitoring of gastrointestinal symptoms is critical, as the use of ibuprofen may exacerbate semaglutide-related gastrointestinal side effects
it speeds up the clearing process so you can go again the next morning
Further studies have found that P53 can inhibit system Xc- uptake of cystine by downregulating the expression of SLC7A11, thereby affecting the activity of GPX4 and resulting in the reduction of antioxidant capacity, ROS accumulation, and ferroptosis 11