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Larger, controlled trials are needed
Babula, P., et al
Hormonal Context Is Not Peripheral What these considerations collectively reveal is that hormonal context is not a secondary variable in how metabolic therapies perform
These two fatty acids are the real stars of the show
Active Ingredients: Riboflavin, Glutathione, Phosphatidylcholine (from Sunflower Lecithin), CoQ10 (Ubiquinol), Pyrroloquinoline Quinone
The trial program has evolved from glycemic-safety and outcomes studies in T2D (the LEADER, SUSTAIN-6, REWIND, EXSCEL, and PIONEER 6 era [10][13], [19]), to outcomes trials in expanded populations including obesity without diabetes (SELECT [3]), HFpEF with obesity (SUMMIT [5], with a companion semaglutide program in STEP-HFpEF [20], [21]), CKD (FLOW [22]), and an active-comparator setting (SURPASS-CVOT [6])
