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Enzymes included in the UGT1 and UGT2 subfamily are responsible for the glucuronidation of exo and endogenous compounds, whereas members of the UGT3 and UGT8 subfamilies have their distinct functions (See section ) (Mackenzie et al., 2008)
Research shows that people with kidney disease are at very high risk for having cardiovascular events
Ultimately, follow-on assets that are most successful will possess some combination of convenient dosing, demonstrated benefits on the liver/heart/kidney, and improved GI tolerability
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