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Acknowledgments We would like to thank the Reviewers for their time and effort in reviewing our manuscript

Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

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Glutathione, a naturally occurring antioxidant, plays a crucial role in protecting cells from damage caused by free radicals

They actively grew

To address these challenges, considerable effort has been devoted to the development of advanced delivery systems