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Pharmacokinetics and Half-Life Semax is given intranasally because oral bioavailability is effectively zero, gastric and small-intestinal peptidases destroy the peptide on contact

doi: 10.3389/fnut.2020.00143 273 TeuwenL.-A.GeldhofV.PasutA.CarmelietP

This concern appears to stem from glutathione's skin-brightening mechanism, which works by inhibiting melanin production through tyrosinase modulation a temporary, dose-dependent, and generally reversible effect, not an autoimmune depigmentation process like vitiligo