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Two of thesethe molecular adsorbent recycling system (MARS) and the extracorporeal liver assist device (ELAD)were developed in the late 1990s

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Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)

10.3389/fimmu.2018.00675 Front Immunol

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