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If 33-merDGP oligomers are formed, they may damage the epithelial cell network, allowing gluten peptides, bacteria, and other toxins to pass massively into the bloodstream, leading to inflammation and, in celiac disease, autoimmunity
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Results develop gradually over 6-12 weeks for puffiness and pigmentation, 3-6 months for vascular improvement through skin thickening, requiring patience and consistency following realistic timelines
Aged mice were intraperitoneally injected with 5 mg/kg FOXO4-DRI or PBS as a control every other day for three administrations, and effects were assessed 30 days post-treatment
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