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For example, weight loss medications like GLP-1 receptor agonists help to improve blood sugar, blood pressure, and fatty liver

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This isn't necessarily a negative finding, but it is a critical variable that must be accounted for in any preclinical or clinical research setting

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4 Although both GIP receptor agonism and antagonism lead to weight reduction, especially when combined with GLP-1 receptor agonism, genetic evidence indicates that GIP receptor variants that are linked to reduced receptor signaling are associated with a lower body-mass index, the study authors wrote in NEJM