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32 A fatty acid chain attached to Lys 20 in tirzepatide may boost the GLP-1 activity while the GIP activity remains unaffected

PubMed Konig J, Seithel A, Gradhand U, Fromm MF

Many peptides can maintain activity for many years

In another chronic treatment model, treatment with cocaine or morphine increased the activity of extracellular signal-related kinase in the VTA, which is linked to the subsequent increases in tyrosine hydroxylase expression

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