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This copper-binding motif is critical: the apo-peptide (GHK without copper) shows substantially reduced biological activity in most in vitro assays, indicating that the metal center is required for receptor interaction and downstream signaling
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At the molecular level, preclinical models have suggested a multimodal mechanism
Generally well tolerated with a low side-effect profile
La protena unida se disocia (eluye) fcilmente mediante desplazamiento competitivo con tampn que contiene GSH reducido libre (glutatin oxidado, el GSSH no es eficaz para este propsito)
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