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However, prescribing rates remained relatively steady and even decreased slightly through late 2024 and early 2025
In recent years, the anti-inflammatory effect of PDE4 inhibitors has been shown to be mainly related to PDE4B while PDE4D is related to side effects such as digestive tract symptoms
Khorsandi et al
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But, thinking about what we do, I feel good about navigating patients towards the best available treatment for them." Botta also is concerned about patients' access to "life-changing" weight loss medications if supply issues aren't resolved
The excitement around GLP-1 RAs is especially driven by their proven clinical success in type 2 diabetes and obesity, and the fact that theyre now moving far beyond glucose control
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