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Control cells were treated with H 2 O 2 (1 mM) for 30 min as a positive control for increased ROS production

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10.1210/en.2016-1839 28

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Evidence has indicated that regulating the gene expression of TRP-1 and TRP-2 by cAMP is directly associated with MITF, which binds to the M-box sequence (AGTCATGTGCT) located in the tyrosinase distal elements (TDEs) after its activation (22)

Pain is a subjective feeling