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In aged AD model mice, tau is overexpressed, the cerebral microvessels are disrupted, and abnormal malformed vascular masses form, and cortical atrophy occurs (234)

Moreover, surface functionalization with targeting ligands enables precise delivery to specific renal cell populationssuch as tubular epithelial cells and immune effector cellsthereby minimizing off-target toxicity

Liposomes: structure, composition, types, and clinical applications

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The integrity of the BBB model was tested by permeability assays for SF and albumin marker molecules

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