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Answer and interpretation This is probably valproic acid induced hyperammonia encephalopathy (VHE) VHE has been reported secondary to acute VPA overdose and in chronic normal therapeutic dosing, presenting as an acute and profound decreased level of consciousness, with or without increased seizure activity this is usually in association with an increased serum ammonia level (Mock and Schwetschenau, 2008) Patients at higher risk for VHE include those with liver impairment, on multiple anticonvulsants, or have other causes of increased ammonia production
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Journal of Applied Physiology Sikiric P et al
Galitzer who introduced me to this concept
10.1073/pnas.0601001103 Proc
Application 2: Fibroblast Biology Research in Dermal and Tendon Cell Lines Fibroblast biology research examines the cellular biology of connective tissue cells, including fibroblast migration, proliferation, and extracellular matrix production
