It also causes mitochondrial dysfunction, impairing insulin signaling and disrupting glucose metabolism, leading to insulin resistance [50]
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16 Therefore, adjustment of background mealtime insulin is important to prevent hypoglycemia when starting a GLP-1 RA
Increased Protein Synthesis: By boosting protein synthesis, IGF-1 LR3 supports faster muscle repair and growth
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The trial also tracked major adverse cardiovascular events (MACE): hazard ratios of 1.12 (3-component composite) and 0.82 (5-component composite), neither statistically significant