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Research shows that up to two-thirds of lost weight can return within a year of stopping treatment
A patient injecting 5mg weekly from a 5mg/mL concentration uses 1mL volume, while the same dose from a 10mg/mL concentration requires only 0.5mL
This delay in the action of the stomach can lead to symptoms like nausea, vomiting, bloating, early fullness, and abdominal pain
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However, extreme caloric restriction or excessive weight loss can potentially disrupt hormonal balance in both sexes, potentially leading to relative energy deficiency in sport (RED-S) or hypothalamic dysfunction
Dose-response analysis indicates optimal benefits occur after approximately 50 weeks of continuous supplementation, suggesting long-term metabolic remodeling rather than acute effects
