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doi:10.2174/138920211798120763 [4] Carta MG, Loviselli A, Hardoy MC, et al

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SPL UNCLASSIFIED SECTION Data SPL UNCLASSIFIED SECTION Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide (0.03-, 0.07-, and 0.5-fold the MRHD of 15 mg once weekly based on AUC) during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

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Cartilage wears down, inflammation sets in, and range of motion narrows