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In the fibrotic ovary, several studies have demonstrated that metformin attenuates ovarian fibrosis through the modulation of immune cells, fibroblasts, and angiogenesis, and pro-fibrotic and inflammation signaling pathways were involved, particularly in aged or high-fat diet-induce mouse models (McCloskey et al., 2020

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Baseline glucose levels were taken before two doses of linagliptin (3 or 30 mg/kg) were administered by gavage 30 min prior to an oral glucose load (100 l of 20%, wt/vol