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N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

We need to ensure that reproductive health is part of every conversation when these drugs are prescribed to any women of childbearing age

Mitochondrial bioenergetic deficit precedes Alzheimers pathology in female mouse model of Alzheimers disease

Diabetes Obes Metab Seferovi PM, Fragasso G, Petrie M, Mullens W, Ferrari R, Thum T, Bauersachs J, Anker SD, Ray R, avuolu Y, Polovina M, Metra M, Ambrosio G, Prasad K, Seferovi J, Jhund PS, Dattilo G, elutkiene J, Piepoli M, Moura B, Chioncel O, Ben Gal T, Heymans S, de Boer RA, Jaarsma T, Hill L, Lopatin Y, Lyon AR, Ponikowski P, Lainak M, Jankowska E, Mueller C, Cosentino F, Lund L, Filippatos GS, Ruschitzka F, Coats AJS, Rosano GMC (2020) Sodium-glucose co-transporter 2 inhibitors in heart failure: beyond glycaemic control

3.3 Short-chain fatty acids The structural integrity of the BBB is maintained by tightly joined brain endothelial cells, astrocytic end-feet, pericytes, and various transport proteins, which stringently regulate the penetration of substances from the blood into the brain tissue (103)

& Brning, J