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Meta-analyses of randomised controlled trials (RCTs) also confirm that energy-restricted MD interventions yield greater weight loss than control or low-fat diets, particularly when combined with increased physical activity [116]
Reduction in calorie intake is dose-dependant and does not differ between obese and lean subjects.35 The feeling of satiety produced by OXM and GLP-1 is likely due to their effects on the CNS as well as on gastric emptying
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