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metformin reduces hepatic glucose production and improves insulin sensitivity, working via distinct mechanisms

Se estudia por su efecto sinrgico sobre la liberacin pulstil de GH: uno inicia el pulso y el otro ampla la seal, sin elevaciones marcadas de cortisol o prolactina en modelos

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Additionally, studies exploring the role of GLP-1 receptor polymorphisms and neurochemical pathways may help clarify individual differences in response to therapy

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