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For centuries, school teachers on the Mediterranean island of Sardinia have witnessed a curious phenomenon

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3.4 Diabetic retinopathy DR is the most prevalent complication of diabetes mellitus (DM) and suffers one-third of the patients with DM (154, 155)

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Decades of research have highlighted the clinical demerits of abnormally high body weight (BW), with BMIs exceeding 30 kg/m 2 and 40 kg/m 2 correlated with decreased life expectancies of three and 10 years, respectively