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Some people notice mild queasiness, particularly in the morning hours or after larger meals
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Additionally, significantly high serum levels of estrogen (P = 0.0001), progesterone (P = 0.0003), cholesterol (P = 0.0001), globulin (P = 0.0001), albumin (P = 0.05), total protein (P = 0.0001), and were also noted compared to the normal control
Taken together, this also demonstrates that Fc-engineered human IgG variants with altered binding to FcRn behave differently in human and murine model systems, which highlights the importance of accounting for cross-species differences when studying Ab-based therapeutics and FcRn biology [101,102,103]
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