glp 1 indication GLP-1-based therapies for diabetes, obesity and beyond Transformation 2.0: The GLP-1 RAs

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Because the hydrophilicity of the drug inhibits its transport process across cell membranes, metformin must rely on transporters to actively transport in and out of cells (Hardie et al., 2012)

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These finding is not unexpected since GLP-1 may increase natriuresis through the inhibition of many ion exchangers in the tubules which expression decreases with the progression of CKD and interstitial fibrosis and tubular atrophy 33