Colestipol (decrease cobalamin and folate absorption) Methotrexate (inhibits DHFR) Nitrous Oxide (inactivates MS) High Dose Niacin (depletes SAMe and limits pyridoxal kinase = active B6) Theophylline (limits pyridoxal kinase = active B6) Cyclosporin A (decreases renal function and increases Hcy) Metformin (decreases cobalamin absorption) Phenytoin (folate antagonist) Carbamazepine (folate antagonist) Oral Contraceptives (deplete folate) Antimalarials JPC-2056, Pyrimethamine, Proguanil (inhibits DHFR) Antibiotic Trimethoprim (inhibits DHFR) Ethanol Bactrim (inhibits DHFR) Sulfasalazine (inhibits DHFR) Triamterene (inhibits DHFR) Involving yourself with providers who are educated on MTHFR Take supplements that are methylation supportive L-5-MTHF Riboflavin (B2) Methylcobalamin or Hydroxocobalamin Zinc DHA Choline TMG (must be avoided in pregnancy) Magnesium Methyl- B6 NAC Vitamin E (natural forms only) Selenium Glutathione Vitamin C Vitamin D Potassium Probiotics Molybdenum Milk Thistle *****Avoid gluten as 20% of patients with MTHFR have gluten sensitivity and gluten is inflammatory

doi: 10.1016/j.cell.2020.09.058 180 HalimTYSteerCAMathLGoldMJMartinez-GonzalezIMcNagnyKMet al
Provides Antioxidant and Anti-Inflammatory Protection GHK-Cu reduces levels of inflammatory cytokines (IL-6, TNF-) and enhances antioxidant enzymes
Case reports indicate that the effects of semaglutide are monitored using measures like eGFR, albuminuria, and glycaemic control rather than through direct measurement of the drug in routine blood tests
It promotes muscle hypertrophy by increasing nitrogen retention and protein synthesis, giving it potential for applications in athletic fields
Patients with a history of thyroid tumors , including benign or malignant growths, should be thoroughly evaluated before beginning treatment