17 Similarly, in a meta-analysis of 14 RCTs in T2DM patients conducted by Liu et al, tirzepatide was shown to provide superior HbA1c reduction and improved metabolic outcomes compared to placebo, insulin, and all other GLP-1 RAs at all doses examined
A few more serious side effects, like pancreatitis and thyroid C-cell tumors, did appear in some trials, but more testing is needed
This increase could be attributable to the composition of protein substitutes and Tyr supplementation, with additional variability potentially arising from differences in supplementation regimens (dose and frequency) and sampling time (Moritz et al., 2023)
The reaction usually decreases after one or two injections
- Total fat mass : significant reduction in induced obesity models, without concomitant food intake reduction (the effect is truly energetic uncoupling via expenditure, not caloric restriction )
While the direct effects of GLP-1 drugs on HS arent well studied, there are some potential benefits for those with coexisting conditions like diabetes or obesity